Volume 31 Issue 7 Page 414-418, July 2004
To cite this article: Ya-Ling Hsu, Po-Lin Kuo, Lien-Chai Chiang, Chun-Ching Lin (2004) ISOLIQUIRITIGENIN INHIBITS THE PROLIFERATION AND INDUCES THE APOPTOSIS OF HUMAN NON-SMALL CELL LUNG CANCER A549 CELLS
Clinical and Experimental Pharmacology and Physiology 31 (7) , 414–418 doi:10.1111/j.1440-1681.2004.04016.x
Abstract
ISOLIQUIRITIGENIN INHIBITS THE PROLIFERATION AND INDUCES THE APOPTOSIS OF HUMAN NON-SMALL CELL LUNG CANCER A549 CELLS
1. Isoliquiritigenin (ISL) is a natural pigment with the simple chalcone structure 4,2',4'-trihydroxychalcone. In the present study, we report, for the first time, ISL-induced inhibition of the proliferation of the human non-small cell lung cancer A549 cell line.
2. The results showed that ISL not only inhibited A549 cell proliferation, but also induced apoptosis and blocked cell cycle progression in the G1 phase. An ELISA assay demonstrated that ISL significantly increased the expression of p53 and p21/WAF1 protein, which caused cell cycle arrest.
3. An enhancement in Fas and its two ligands, namely membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), may be responsible for the apoptotic effect induced by ISL.
4. Taken together, the results indicate that the p53 and Fas/FasL apoptotic system may participate in the antiproliferative activity of ISL in A549 cells.
- Kun-Hung Shen, Jiunn-Kae Chang, Ya-Ling Hsu and Po-Lin Kuo. (2007) Chalcone Arrests Cell Cycle Progression and Induces Apoptosis through Induction of Mitochondrial Pathway and Inhibition of Nuclear Factor Kappa B Signalling in Human Bladder Cancer Cells. Basic & Clinical Pharmacology & Toxicology 101:4, 254–261
- Rong-Xia Liu, Li Li, Qiao Wang, Wei Wang, Kai-Shun Bi, De-An Guo. (2005) Simultaneous Determination of Nine Flavonoids in Dalbergia odorifera by LC. Chromatographia 61:7-8, 409
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Correspondence: Professor Chun-Ching Lin, Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, no. 100, Shin-Chuan 1st Road, Kaohsiung 807, Taiwan. Email: aalin@ms24.hinet.net
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